[HTML][HTML] Enzymatic reaction mechanism of cis-aconitate decarboxylase based on the crystal structure of IRG1 from Bacillus subtilis
HL Chun, SY Lee, SH Lee, CS Lee, HH Park - Scientific Reports, 2020 - nature.com
… that for iminodisuccinate (IDS) epimerase, a structural homolog of … exhibits the typical fold of
the MmgE/PrpD family containing two … cis-aconitate is docked into this defined grid box of the …
the MmgE/PrpD family containing two … cis-aconitate is docked into this defined grid box of the …
[HTML][HTML] In-silico characterization and structure-based functional annotation of a hypothetical protein from Campylobacter jejuni involved in propionate catabolism
… the HP with other MmgE/PrpD family protein and cis-aconitate … and a smaller domain that
folds into an alpha + beta domain [… proteins with an unknown three-dimensional structure, and …
folds into an alpha + beta domain [… proteins with an unknown three-dimensional structure, and …
[HTML][HTML] Characterization and engineering of branched short-chain dicarboxylate metabolism in Pseudomonas reveals resistance to fungal 2-hydroxyparaconate
… A unique function within the MmgE/PrpD family was revealed for an iminodisuccinate (IDS) …
MmgE/PrpD family protein shared the highest structure identity with the IDS epimerase from A…
MmgE/PrpD family protein shared the highest structure identity with the IDS epimerase from A…
Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis
F Chen, P Lukat, AA Iqbal, K Saile… - Proceedings of the …, 2019 - National Acad Sciences
… structure of hCAD (comprising residues 4 to 461) was determined by molecular replacement
with the structure of iminodisuccinate epimerase (… the same fold as the mammalian proteins, …
with the structure of iminodisuccinate epimerase (… the same fold as the mammalian proteins, …
[HTML][HTML] The crystal structure of mouse IRG1 suggests that cis-aconitate decarboxylase has an open and closed conformation
HL Chun, SY Lee, KH Kim, CS Lee, TJ Oh, HH Park - Plos one, 2020 - journals.plos.org
… The structure was determined using the molecular replacement (MR) phasing method with
PHASER [24]. The previously solved structural homologue iminodisuccinate (IDS) epimerase …
PHASER [24]. The previously solved structural homologue iminodisuccinate (IDS) epimerase …
ACOD1 in immunometabolism and disease
… , with a 25-fold increase in induction. The human ACOD1 … In addition, a miRNA is defined
as a 21–25 nucleotide single-… structure, technical modifications of the ACOD1 protein to …
as a 21–25 nucleotide single-… structure, technical modifications of the ACOD1 protein to …
[HTML][HTML] Crystal Structure of an Active Site Mutant Form of IRG1 from Bacillus subtilis
HH Park - Crystals, 2021 - mdpi.com
… structural analysis showed that the active site composition of bsIRG1 is more similar to that
of epimerase … relationship between decarboxylase activity and epimerase activity of bsIRG1. …
of epimerase … relationship between decarboxylase activity and epimerase activity of bsIRG1. …
[PDF][PDF] Crystal Structure of an Active Site Mutant Form of IRG1 from Bacillus subtilis. Crystals 2021, 11, 350
HH Park - Crystallographic Studies of Enzymes (Volume II), 2021 - mdpi.com
… In this study, we determined the high-resolution structure of the active site … Three-dimensional
structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family…
structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family…